Animal reproduction scientific tests haven't been performed Along with the drug mixture-promethazine and codeine. It's not at all regarded no matter whether this drug mix could potentially cause fetal damage when administered to a Expecting woman or can have an impact on copy ability.
The commonest Unwanted effects are drowsiness, modifications in hypertension, skin reactions, blood cell modifications and breathing challenges. Improved excitability or irregular actions could manifest right after a person dose of promethazine. If they do, talk to your doctor about employing A further medicine.
patients who're allergic to promethazine, any of the components in promethazine, or to other phenothiazines
The treatment method of choice for resulting hypotension is administration of intravenous fluids, accompanied by repositioning if indicated. In case vasopressors are thought of with the administration of critical hypotension which won't reply to intravenous fluids and repositioning, the administration of norepinephrine or phenylephrine need to be thought of.
The administration of promethazine HCl in 25 mg doses will control minimal transfusion reactions of an allergic character.
Promethazine Carcinogenicity scientific studies were executed with promethazine hydrochloride. Two-year scientific studies in F344/N rats and B6C3F1 mice were carried out to assess the carcinogenic prospective of promethazine hydrochloride. No evidence of tumorigenicity was noticed in male and woman rats at promethazine hydrochloride oral doses up to 33 mg/kg/day for five days/week (somewhere around akin to ten occasions the MRHD over a mg/m2 foundation).
As a result of very similar pharmacologic properties, it really is acceptable to expect equivalent chance with concomitant usage of opioid cough medications and benzodiazepines, other CNS depressants, or Liquor.
Long-expression animal scientific studies haven't been performed to evaluate the carcinogenic prospective of Promethazine, nor are there other animal or human details about carcinogenicity, mutagenicity, or impairment of fertility using this drug. Promethazine was nonmutagenic from the Salmonella take a look at technique of Ames.
Indications and signs of overdosage with Promethazine HCl vary from delicate depression in the central nervous procedure and cardiovascular process to profound hypotension, respiratory melancholy, unconsciousness, and sudden Loss of life.
Codeine is thought to be subject matter to abuse; even so, the abuse possible of oral codeine seems to get rather reduced. Even parenteral codeine doesn't surface to offer the psychic outcomes sought by addicts to exactly the same diploma as heroin or morphine.
It really is strongly encouraged that an exact measuring unit be employed. A pharmacist can offer an suitable system and can offer Recommendations for measuring the right dose.
Overdose of codeine in Grownups has long been linked to deadly respiratory despair, and using codeine in youngsters youthful than 12 a long time of age has long been linked to lethal respiratory melancholy when utilised as encouraged [see Warnings and Safety measures (five.
Lactation Not less than just one Loss of life was claimed in the nursing infant who was exposed to high levels of morphine in breast milk as the read more mother was an extremely-fast metabolizer of codeine.
Nearly all of research examining the usage of promethazine in pregnancy didn't find an Affiliation with an increased hazard of congenital anomalies. While in the couple of experiments reporting an association, no regular sample of malformations was famous.